Historic Prague is one of the crowning jewels of Central Europe, and guests of local hotels have more sightseeing and museum-hopping to do than time permits. Period architecture is everywhere, some of which dates as far back as the 13th century. A mix of luxury hotels and atmospheric inns are on hand catering to every budget.

Most of the hotels are located in the old and new towns, both of which are historic and full of impressive architecture. Wenceslas Square in the New Town is more upscale, operating deluxe hotels on the main strip within access of innumerable restaurants, bars and bohemian cafés. There is a nice blend of upscale, independently-owned establishments and well-known international chains, both of which offer excellent services and amenities.

The Hotel Palace Praha is one of the best-known establishments in the city. The building itself is one of the finest Art Nouveau specimens in Prague, and the service here is excellent. Crown Plaza Prague is another popular choice, especially for transit and business travellers who want to stay within easy reach of the airport. The Marriot in the city centre is particularly luxurious, with spacious rooms and excellent facilities including a comprehensive fitness centre.

The historic centre of Prague is tied up in Mala Strana, or the Lesser Side. Baroque architecture and grandiose palaces built by Catholic nobles several centuries ago line the streets. Visitors staying in this part of town get an authentic taste of old-world Prague, complete with the opportunity to listen to classical recitals at the Church of St Nicholas. During the Christmas season, hotels with access to the Christmas Market charge premium rates.

In Nove Mestro, or the New Town, Wenceslas Square hosts several top-end hotels and a vibrant café and bar scene. Period architecture from as far back as the 1200s is also on display here, leaving plenty of room for sightseeing.

Hradcany perches on a hill overlooking the city centre and offers guests an unparalleled view of the old and new towns. Gardens, museums and trademark attractions like St Vitus Cathedral and Prague Castle can all be viewed here.

For a more relaxed experience, consider staying in the suburbs to the north and west of the city centre. Expansive parks and the former summer palace of the royal family set the stage for leisurely walks.

Josefov, or the Jewish Quarter, is a unique part of the city with plenty of atmosphere. This district boasts several historic synagogues and Jewish museums. Staying in Josefov is a nice alternative to Wenceslas Square as it's quieter but still within easy walking distance of the restaurant and bar scene.